Senior Scientist, Mass Spectrometry

Vacancy Reference Number

1259320EB

Organisation:

AstraZeneca

Closing Date

24 Jun 2021

Salary

TBC

Address

AstraZeneca, Charter Way, Macclesfield, SK10 2NA

Duration

Permanent

Duties and Responsibilities: Comprehensive characterisation of drug product formulations of large molecules and complex drugs such as, oligonucleotides, to elucidate their critical quality attributes. Playing a lead role in the identification, evaluation and implementation of cutting edge analytical capabilities in the field of mass spectrometry to build and improve product characterisation capability. Developing robust analytical methodologies and control strategies to support projects. Ensuring that work is performed in accordance with appropriate Safety, Health & Environment (SHE), quality and compliance standards, e.g. Good Manufacturing Practice (GMP), Good Laboratory Practice (GLP).

Skills & Capabilities: Degree (Masters or PhD) in Chemistry, in Analytical Sciences, or a related subject Experience of working with chromatographic methods, hyphenated to mass spectrometry with focus on ESI/MS/MS and CID for the analysis and characterisation of high molecular weight species, such as peptides, oligonucleotides, polymer conjugates etc. Ideally, this would include sample preparation, impurity identification and software tools for rapid data processing. The ability to tackle complex scientific problems and LC / MS troubleshooting. Excellent communication and stakeholder skills, and the ability to discuss complex ideas in a simple, easy to understand way to wide groups of stakeholders.

Desirables: Expertise in complex data analysis and digital science. Experience in characterising nucleic acid based therapeutics Knowledge and industrial experience of pharmaceutical development, in a GMP environment (especially parenteral formulations) Direct experience in analytical method development and validation in a commercial laboratory setting. Strong influencing skills and prioritisation skills to ensure project delivery (We Follow The Science & We are Entrepreneurial)

Further Information

https://astrazeneca.wd3.myworkdayjobs.com/Careers/job/UK---Macclesfield/Senior-Scientist--Mass-Spectrometry_R-109687-1

Contact Details

07833402360