(Senior) Scientist, Chemoproteomics

Vacancy Reference Number

Chemoproteomics

Organisation:

Bind Research

Closing Date

16 Apr 2025

Salary

Industry competitive

Address

Kings Cross Area, London

Duration

Permanent

Role Overview

We are seeking a Senior Scientist in Chemoproteomics to lead, develop, implement, and optimise cutting-edge experimental methods for mapping proteome-wide small-molecule interactions. The successful candidate will design and execute high-throughput chemoproteomics experiments, work closely with a strong AI team to develop predictive models, and contribute to the creation of an interactive platform to share and analyse proteome-wide interaction data.

Key Responsibilities

1. Chemoproteomics Strategy & Experimental Execution

Develop and optimise chemical proteomics workflows for large-scale identification of small-molecule interactions with intrinsically disordered proteins.
Apply photoreactive and bioorthogonal probes to map interactions in intact cells.
Utilise quantitative mass spectrometry (LC-MS/MS, TMT-based proteomics) to analyse small-molecule–protein interactions.
Expand fragment-based ligand discovery (FBLD) approaches to intrinsically disordered and challenging proteins.
 

2. Driving innovation

• Stay up to date with advancements in chemoproteomics, disordered proteins, and mass spectrometry, and translate these developments into novel experimental and analytical approaches.
• Contribute to the design and execution of innovative mass spec-based research projects, particularly through the integration of AI and mass spec methodologies to advance Bind’s scientific objectives.

3. Team Collaboration and Training

• Collaborate with computational scientists to build a predictive ligand discovery platform.
• Mentor and support Bind’s interdisciplinary team in experimental design, execution, and data interpretation.
• Train team members in chemoproteomics workflows, mass spectrometry techniques, and analysis.

4. Capability & Infrastructure Development

• Establish and manage collaborations with external mass spectrometry labs in Central London, ensuring seamless access to off-site proteomics workflows.
• Serve as the primary liaison for mass spec facility partnerships, coordinating sample preparation, data acquisition, and analysis with external teams.

Qualifications and Expertise

Education

• PhD in Biology, Chemistry, Biochemistry, or a related field with a specialisation in (chemo-)proteomics and/or mass spectrometry.

Skills and Experience

• Hands-on experience with quantitative proteomics (TMT, SILAC, label-free quantification) and LC-MS/MS methods.
• Expertise in photoaffinity labelling, bioorthogonal chemistry, and fragment-based ligand discovery (FBLD).
• Experience with small-molecule screening approaches for protein interaction studies.
• Expertise in mass spectrometry data processing pipelines (MaxQuant, Proteome Discoverer).
• Experience integrating multi-omics datasets.

Nice to have

• Python programming skills (NumPy, SciPy, Pandas).
• Experience working with intrinsically disordered proteins.
• Experience working with data visualisation software (Perseus)

Additional Attributes

• A creative mindset with a passion for advancing mass spectrometry.
• Enthusiasm for training and mentoring team members at all levels of mass spec expertise.
• A collaborative approach, with a willingness to engage in team-based research initiatives.
• Commitment to continuous professional development in mass spec.
• Passion for contributing to the establishment and growth of a world-class research organisation.

Further Information

Bind Research is an innovative not-for-profit research organisation at the forefront of developing tools and datasets to characterise small-molecule interactions with intrinsically disordered proteins. Based in central London, Bind leverages interdisciplinary methods spanning chemoproteomics, experimental biophysics (NMR spectroscopy), and computational approaches. You will play a crucial role in shaping the future of this cutting-edge research initiative from the beginning.

Join Bind Research to push the limits of drug discovery for intrinsically disordered proteins through large-scale chemoproteomics, experimental biophysics, and AI-driven ligand prediction.

See more info at bindresearch.org: https://bindresearch.org/job-chemoproteomics/

Contact Details

careers@bindresearch.org