Senior Scientist

Vacancy Reference Number

GSL-005

Organisation:

Guilford Street Laboratories

Closing Date

14 Mar 2025

Salary

Competetive

Address

UCL Great Ormond Street Institute of Child 30 Guilford Street, London, WC1N 1EH

Duration

Permanent

This is a full-time on-site Senior Scientist role located in central London. The Senior Scientist will be responsible for leading on the development of our LC-MS/MS cardiac diagnostic program. Key aspects of the role include, but are not limited to:

• Validate targeted LC-MS/MS proteomic assays to clinical standard (ISO15189, CLIA)
• Independently applies scientific principles to achieve project objectives, including the design and execution of complex experiments, and analysis and interpretation of data under limited supervision
• Assessing viability and feasibility of new assays
• Conduct biomarker discovery analysis for new biomarkers within the cardiac workstream
• Execute project deliverables for biomarker studies in clinical trials by project scope of work and within sponsor-specific timelines.
• Manage day-to-day operational aspects of clinical biomarker projects.
• Assist in preparation and adherence to trial documents i.e., Project Protocols, Data Transmittal Forms etc.
• Ensure project documentation are complete, current, and stored appropriately.
• Manage key documents/processes i.e., Project Management Plan, Risk Management Plan, and Clinical Trial Management Systems (CTMS).
• Identification of scope out quests – working with appropriate team(s) to revise work orders to meet changing needs and requirements.
• Prepare metrics reporting for client and senior management.
• Manage Core Lab Resources and ensure timely delivery of analysis.
• ​Creating and Contributing to Standard Operating Procedures of the overall service, and individual projects.
• Direct Customer engagement
• Liaise with external study teams to ensure smooth delivery of project metrics – this may include attendance at progress meetings as required.
• Some domestic and international travel will be required.
• Contribute to laboratory duties to maintain smooth laboratory operation
• Troubleshoot equipment issues
• Adhere to laboratory safety protocols and human tissue sample handling procedures
• Carry out any other duties as are within the scope, spirit and purpose of the job as requested by the Line Manager.

Qualifications

• PhD in biochemistry/related subject desirable
• 3+ years’ experience in mass spectrometry operation and method development essential
• Experience in heart failure/cardiomyopathy research desirable
• Quality Assurance/Compliance in clinical trials settings; Experience in Clinical trials/mass spectrometry in a clinical environment desirable
• Experience in leading research projects desirable
• Proficiency in scientific writing, report generation, and presentation skills
• Ability to collaborate effectively with cross-functional teams

Further Information

At Guilford Street Laboratories (GSL), our mission is to revolutionise biomarker discovery and development by harnessing the power of proteomics and machine learning (ML). We are dedicated to improving diagnostics and advancing treatment options in rare, cardiac, and neurodegenerative disease. Through cutting-edge mass spectrometry and ML algorithms, we develop panels of biomarkers that can be used to diagnose, stratify and monitor patients across the entire clinical pathway.

Contact Details

Dr Tom Baldwin tomas.baldwin@guilfordstreetlabs.com