BRITISH MASS SPECTROMETRY SOCIETY
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Investigator, Expert Mass Spectrometrist - GSK

Date Posted: 22/03/18
End date for submission of applications: Monday 9th April 2018 at 17:00 GMT

Job Description:

GSK is a science-led global healthcare company with R&D playing a fundamental role in helping GSK to achieve its mission – enabling people to do more, feel better and live longer.  The Analytical Sciences and Development (ASD) department, part of Product Development & Supply, undertakes critical expert work in supporting the drug development process as well as existing products, to deliver new medicines to patients by accelerating access to novel medicines, preventions and cures.

The Global Spectroscopy (GS) group, part of ASD, is responsible for all the spectroscopic activities that take a drug candidate from earliest development into manufacturing. As part of this, the spectroscopy group solves structural chemistry problems for biologists, chemists and analysts in PTS by making intelligent and coordinated use of MS, NMR, vibrational spectroscopy and allied hyphenated techniques. The group uses state-of-the-art equipment in a modern laboratory and works closely with biologists, chemists, analysts and other spectroscopists around the world in GSK.

We currently have a vacancy in the spectroscopy group for a mass spectrometrist. The principle duties of the role are::

  • To work as part of the spectroscopy team using mass spectrometry to provide a key part of our primary structure elucidation function.
  • To develop and apply new MS methods to analytical problems from Metabolism and Synthetic Chemistry, and to design and implement experiments which apply mass spectrometry to solve problems in new ways.
  • To take part in multi-disciplinary teams to solve problems by the most effective route, using a knowledge of other key analytical techniques, especially chromatography, NMR, infrared and Raman.
  • To evaluate results and provide reports on the work performed.
  • To evaluate, introduce and apply new technology in MS, contributing to the strategic development of the spectroscopy group.
  • To troubleshoot experimental and instrumental problems.

Basic qualifications:

  • Proven track record of structural characterisation/elucidation work of small molecules by mass spectrometry (LC-MS and/or GC-MS) – identification of metabolites, impurities, and/or degradants by mass spectrometric techniques.
  • Ph.D.in Analytical Chemistry, preferably in a mass spectrometry related discipline.
  • Knowledge of state-of-the-art high resolution LC-MS instrumentation for example Q-Tof and Orbitrap mass spectrometers.

Preferred Qualifications/Experience:

  • Experience in analysis of oligonucleotides by mass spectrometry would be an advantage.
  • Proven track record of development of novel LC-MS and GC-MS methodology in the pharmaceutical (or related) industry.
  • Experience in optimising, developing and troubleshooting chromatographic and MS methods.
  • Experience in developing quantitative trace analysis methods using mass spectrometric techniques.
  • Experience in regulated GxP laboratory.
  • Strong communication and interpersonal skills.
  • Project leadership skills.
  • Familiarity with regulatory submission documents.
  • Knowledge of spectroscopic techniques other than mass spectrometry would be an advantage, e.g. NMR, vibrational spectroscopy.

Please submit your application via: https://goo.gl/w3otkr

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application..

Thank you for your interest in this opportunity.

Salary:

Competitive + Benefits


Trace Analysis Investigator, Mass Spectrometry - GSK

Date Posted: 22/03/18
End date for submission of applications: Monday 9th April 2018 at 17:00 GMT

Job Description:

GSK is a science-led global healthcare company with R&D playing a fundamental role in helping GSK to achieve its mission – enabling people to do more, feel better and live longer.  The Analytical Sciences and Development (ASD) department, part of Product Development & Supply, undertakes critical expert work in supporting the drug development process as well as existing products, to deliver new medicines to patients by accelerating access to novel medicines, preventions and cures.

The Global Spectroscopy (GS) group, part of ASD, is responsible for all the spectroscopic activities that take a drug candidate from earliest development into manufacturing. As part of this, the spectroscopy group solves structural chemistry problems for biologists, chemists and analysts in PTS by making intelligent and coordinated use of MS, NMR, vibrational spectroscopy and allied hyphenated techniques. The group uses state-of-the-art equipment in a modern laboratory and works closely with biologists, chemists, analysts and other spectroscopists around the world in GSK.

We currently have a vacancy for a scientist who is looking for an opportunity to develop their trace analysis expertise and knowledge of Extractable and Leachables (E&L) analysis and mutagenic impurity control strategies to join GSK’s GS team.  In this exciting role, you will have responsibility and accountability for the delivery of high quality data sets and the associated trace analytical methods, with which you will be expected to present key knowledge and understanding into regulatory submissions for a portfolio of small molecule, biopharmaceutical and/or cell & gene therapy projects supported within Analytical Sciences and Development.  You will use your expertise in trace analysis to effectively and efficiently reduce project risk and contribute to the control strategies for drug product.

Key responsibilities:

  • To work as part of the spectroscopy team and provide technical leadership within the subject area of extractables and leachables and mutagenic impurities.
  • Provide expert functional, project and cross-project advice as a subject matter expert in the field of trace analysis for leachables and mutagenic impurities including conducting risk assessments, contributing to project reviews and control strategy development, plus authoring and/or reviewing relevant sections of regulatory submissions.
  • Ensure scientific rigour, discipline excellence and data integrity through technical review and oversight, training and mentoring of staff.
  • Use external networks/collaborations with industry and academia as appropriate and direct/encourage progression of science for GSK.
  • Represent Global Spectroscopy on internal analytical networks, technical fora and/or project teams as required.

Basic qualifications:

  • Ph.D in Analytical Chemistry, preferably in a mass spectrometry related discipline.
  • Experience of quantitative analysis using mass spectrometry.
  • Strong communication and influencing skills.
  • High level of problem solving capability.
  • Proven track record of generating high quality data and technical report writing.

The successful candidate will be a strong leader, have a track record of delivery, possess excellent verbal and written communication skills, diligently follow quality and safety guidelines, work well in multidisciplinary teams and effectively prioritise workload of themselves and other staff members.

Please submit your application via: https://goo.gl/WKfoQK

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.

If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.

When applying for this role, please use the 'cover letter' of the on-line application to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

Thank you for your interest in this opportunity.

Salary:

Competitive + Benefits


Field LCMS Application Specialist (m/f) - Agilent Technologies

Date Posted: 23/01/18
End date for submission of applications: 28/04/18

Job Description:

Agilent is the premier laboratory partner for a better world. We provide life science, diagnostic and applied market laboratories worldwide with instruments, services, consumables, applications and expertise. Agilent enables customers to gain the insights they seek – so they can do what they do best: improve the world around us. Information about Agilent is available at www.agilent.com.

We are currently looking for a LCMS Field Application Specialist (m/f) to join the dynamic Sales Team of UK and Ireland.

You will be a part of the European Sales Organization in the Agilent's Life Sciences and Applied Markets Group. 
In this position, you will deliver superior instrument and workflow demonstrations and application support to customers, interact with Sales Managers, Account Managers and Product Specialists. The position requires a strong background in mass spectrometry, can be based in a variety of locations and will require at least 75% travel. It is important that you are proactive, communicative and a strong team player.

Responsibilities:

  • Demonstrate the latest, state-of-the-art, LC-MS (single quad, triple quad and Q-TOF) technology at customer sites or in the Agilent Centers of Excellence in Cheadle (UK)
  • Position the results to customers through presentations, seminars and application notes 
  • Understand customer's challenges, recommend solutions, and ensure highest customer satisfaction
  • Travel to customer’s sites to present results, implement methods, provide application consulting and deliver on-site customer trainings classes 
  • Train Agilent sales team about LCMS technology, the latest instrumentation and MS based solutions 
  • Work with the sales teams to exceed LC-MS sales targets 

Qualifications:

  • Bachelor's or Master Degree in Analytical Chemistry or equivalent
  • Knowledge of LC and LCMS technology and its operations
  • Experience with Agilent software, HPLC and/or mass spectrometry products is an advantage Ideally some industry experience in an MS environment
  • Excellent presentation, communication and customer facing skills is required
  • Good team working skills
  • Excellent problem-solving skills
  • Fluent verbal & written English skills 

Should you have any further questions in regards to the application process, please contact Blanka Demeter on +36 1 883 5287

To apply, please visit our Careers Page - Requisition 2075044

Salary:

Competitive.

Contact Details:

Blanka Demeter
Email: Europe_staffing.coordinator@agilent.com 


Product Development Engineer - Microsaic Systems plc

Date Posted: 11/01/18
End date for submission of applications: 31/03/18

Job Description:

The candidate will work in a focussed engineering team and will play a role in all stages of product development. The ideal candidate will have a solid foundation in the core scientific areas (physics, physical chemistry and analytical chemistry) and will be familiar with key technologies (mass spectrometer systems, electron/ion sources, vacuum systems and ion optics) with strong analytical and empirical skills. The individual will be a good troubleshooter with laboratory, instrumentation, and PC-based data acquisition experience. The candidate will be a fast learner with a track record of meeting tight deadlines. Key attributes include initiative, commitment and flexibility. UK residency is a must.
 
Qualifications

  • MSc/PhD level degree in physics or chemical physics

Experience

  • 3+ years relevant research and development experience.
  • Design, development and test of mass spectrometers, liquid chromatography, ion sources, ion optics and vacuum systems
  • Molecular diagnostics, analytical instrumentation background an advantage

Core skills

  • Conversant with mass spectrometers and their use
  • Good understanding of the physics and chemistry of mass spectrometry
  • Practical experience of vacuum systems design and development
  • Proven DoE approach to scientific investigations

Preferable skills

  • Modelling of ion optics (Simion, Amaze)
  • Physical modelling, CFD experience (OpenFOAM, COMSOL, ANSYS)
  • Mechanical CAD skills (AutoCAD, SolidWorks)
  • Excellent written and oral communication skills
  • Ability to automate testing and data processing/analysis (Python, VB, Labview, Lua, etc)

Specific Duties

  • Development of mass spectrometers, ion sources and vacuum systems
  • Testing and debugging instruments
  • Being technical point of contact with existing customers
  • Analysing and solving customer problems
  • Providing feedback to engineering
  • Test/Repair/Calibration/Customisation of instruments 

Salary:

Negotiable

Contact Details:

Richard Moseley, Chief Technologist
Email: rmoseley@microsiac.com


 


 
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