PhD Studentship –Swansea University Medical School
Date Posted: 23/11/18
End date for submission of applications: 22/02/19
(SURESSUMS01) Lipid Biomarkers Discovery: From Lysosomal Storage Disorders To Neurodegenerative Diseases
Contact: Professor Yuqin Wang (email@example.com), Professor Mike Gravenor (firstname.lastname@example.org) and Professor William Griffiths
Mounting evidence suggest that dysfunction of mitochondria, of the autophagy-lysosome system and of vesicle trafficking pathways play an important role in the pathobiology of neurodegenerative diseases. Lipids are key components of these systems being critically involved in membrane structures. Lipid molecules also provide an energy store in cells and act as signalling molecules within and between cells. Hence, lipid profiles, both intracellular and secreted, are relevant indicators of cellular homeostasis.
Abnormal lipid metabolism is a common feature of numerous lysosomal storage disorders (LSDs), some of which have established phenotypic and genetic links to Parkinson’s Disease (PD) and Alzheimer’s Disease (AD). For example, the lysosomal disorder Gaucher disease is caused by mutations in the glucocerebrosidase gene (GBA), which results in accumulation of glucosylceramide and also high cellular cholesterol levels. Interestingly, mutations in GBA are a leading genetic risk factors for PD. We want to determine whether lipids can serve as potential biomarker for different neurodegenerative diseases. We will exploit mass spectrometry (MS)-based lipidomic methods for the unbiased quantitative profiling of lipids in human biospecimens.
Details of the application process can be found here.
Scholarships include fees at Home/EU rate and a maintenance stipend at UKRI rates, each for a maximum period of three years
Professor Yuqin Wang
Professor William Griffiths
Research Lab Manager in Chronobiology – School of Biosciences & Medicine, University of Surrey
Date Posted: 20/11/18
End date for submission of applications: 02/12/18
This exciting opportunity has arisen and is associated with the Metabolomics Core Facility and the research of the Chronobiology Section led by Professor Debra Skene.
The Chronobiology Section has pioneered the use of untargeted and targeted UPLC-MS metabolomics to investigate24 h rhythms, circadian and sleep/wake processing in a range of species, including humans. We are seeking a candidate experienced in liquid chromatography-mass spectrometry (LC-MS) analysis to plan and run metabolomics studies within the facility. The position will involve analysing biological samples from metabolic studies across the School and may involve working with external collaborators. As such we are looking for a good team player with experience of LC-MS metabolomics analysis to oversee the running of the equipment, prepare samples, perform targeted quantitative LC-MS analysis and liaise with researchers within and outside of the University of Surrey.
This position would suit someone with excellent attention to detail, substantial LC-MS experience and an interest in metabolism/chronobiology. Previous experience of data analysis would be beneficial to the successful applicant to support the training provided. In addition to further developing existing knowledge/skills in Mass Spectrometry-Metabolomics; this position will provide opportunities to work alongside experienced team of laboratory technicians from a range of backgrounds, attend research seminars and build professional contacts across the Faculty of Health & Medical Sciences.
In addition to your salary, you will receive a generous annual leave entitlement and pension, along with excellent career development opportunities to help you fill your potential. The University of Surrey is located on a beautiful, leafy campus in Guildford, just 30 miles from London and benefitting from excellent rail and road connections.
To apply and find out more about this position and how to apply, please click here.
£32,236 to £35,211 per annum pro rata (0.8 FTE)
Prof Debra Skene
Mass Spectrometry Specialist (1704350) - Syngenta
Date Posted: 22/09/18
End date for submission of applications: 19/12/18
Syngenta is a leading agriculture company helping to improve global food security by enabling millions of farmers to make better use of available resources more sustainably. Through world class science and innovative crop solutions, our 28,000 people in over 90 countries are working to transform how crops are grown. We are committed to rescuing land from degradation, enhancing biodiversity and revitalizing rural communities.
About this role:
To provide expertise in solving demanding structural challenges and delivering innovative technical solutions that enable Product Metabolism and Analytical Sciences (PMAS) to build an understanding of the metabolism of chemicals.
- Design and implement targeted analytical methodology to suit the needs of current projects.
- Provide advice on, and interpret MS data of metabolites of our active ingredients
- Advise on, and perform, appropriate follow-up analytical experiments required to answer structural challenges
- Integrate data from multiple sources, and advise users of its implications
- Participate in PMAS project teams & interpret results for use by project teams
- Independently provide expert technical assistance to external suppliers, where appropriate, to facilitate transfer of technical know-how
- Work flexibly within the team to maintain instruments, propose and implement improvements to optimise the capability and capacity of our systems
- Maintain compliance with Syngenta HSE requirements
- Qualification or work experience to degree level in chemistry or another relevant degree
- Strong theoretical understanding of MS of small molecules and ideally practical experience optimising instrumental performance in an industrial or postgraduate environment
- Established knowledge of the acquisition and interpretation of MS data
- An understanding of chemical structures is essential and a grasp of synthetic chemistry mechanisms would be advantageous
- Industrial or postgraduate experience in the application of mass spectrometry to the determination of small molecule chemical structures
- A proven record of achievement in delivering customer-focused solutions to agreed timescales
Critical technical, professional and personal capabilities
- Strong desire and ability to learn/develop new skills and maintain current awareness of spectroscopic science
- Capability to acquire and interpret mass spectrometry data of challenging small molecules
- Ability to work as part of a team to integrate data from multiple sources to solve demanding structural challenges
- Ability to prioritise between different work demands
Syngenta will offer:
- Campus environment
- Competitive benefits package
- 31.5 days holiday
- The opportunity to work with and learn from highly qualified and experienced employees
Apply online here
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